Week 2 NFL Picks: Latest Betting Odds, Vegas Spreads and Projections rebuilding San Francisco 49ers on Monday Night Football. Week 2 of the NFL preseason is coming up quickly. NFL Preseason Week 2 TV Schedule, Odds And Expert Predictions Against The Spread the weekend, culminating with the season's first Monday Night Football. Ravens are the biggest favorites in Week 2 of the NFL season. small underdogs in their visit to Chicago on “ Monday Night Football.”.