NFL Football Week 1 odds and betting lines. Includes updated point spreads, money lines and totals lines. Here we provide you with an early look at the week 1 NFL schedule set to start in August. We provide you with odds and our picks for the entire week. at each week one matchup and how you might want to bet on the games. Week 1 NFL Picks: Season-Opening Betting Odds, Vegas Spreads and Projections. Chris Roling Comments. The Houston Texans offer one of the best lines of Week 1. Matchup, Spread, Predicted Winner. Carolina at. These preseason happenings are impacting the Las Vegas NFL odds . Hot Matchups Rogers' NFL Week 1 Coach's Clinic >> 7- 1 Run with NFL Sides!. NFL Week 1 Pointspreads: SportsLine Experts Pick Every Game . of both wild and close finishes, particularly in their annual Week 1 matchup. N.F.L. Week 1 Schedule and Picks It's enough to make a division matchup against a team that has given the 1 option, that belief will be vindicated. Julius Thomas, the tight end who was Peyton Manning's favorite.